Drug nutrient interaction a pysicochemical, physiological or pathophysiological process that alters disposition, function or toxicity of a food component or. The nutrientnutraceuticalherbdrug interaction database can help consumers, patients and health care professionals define the interactions synergies and contraindications of various treatments to maximize the potential of complementary drug plus natural agent health care and treatment outcome. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Pbps are enzymes that are involved in the last stages of assembling the bacterial cell wall and in. Proper use of imipenem and cilastatin intravenous route, intramuscular route to help clear up your infection completely, imipenem and cilastatin combination must be given for the full time of treatment, even if you begin to feel better after a few days. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6. Compatibility of imipenemcilastatin sodium with commonly. Antigone kouris phd, from authoritative fully referenced sources. Provides a summary of interactions with vitamins, herbs, and food. If you have an allergy to imipenem, cilastatin, or any other part of imipenem and cilastatin. This database allows you to find potential drug and nutrient interactions that could affect your recommendations. Drugdrug interactions valproate a 46yearold man with bipolar schizoaffective disorder was given divalproex extendedrelease 1500 mgday and 2000 mg at bedtime. With rapidly growing research and technology, medications are more beneficial, and new ones continue to be discovered. Handbook of drugnutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drugnutrition interactions which will act as a reliable reference for clinicians and students for many years to come.
The foremost drugnutrient interaction resource for over 33 years. Nutrientdrug interactions nutritional disorders msd. Zofran is a brand name for the drug ondansetron, prescribed to treat or prevent nausea and vomiting. The handbook of drug nutrient interactions, second edition, addresses the complex interactions between both dietary components and their impact on drug absorption, distribution, and elimination as well as the effects of specific pharmacologic agents on nutritional health.
It is made from a combination of imipenem and cilastatin. The sodium content should be considered when these products are used in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention. The drugnutrient interactions may alter this absorption by reducing emptying time of the digestive system through formation of chelates, originated from reactions between metallic cations present in the matrix of foods and drugs, due to their physical and chemical characteristics, as well as by changes in absorption of fats, fat. Handbook of drugnutrient interactions, second edition is an essential new work that provides a scientific look behind many drugnutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. The values of t90 for imipenem in solutions stored at 4 degrees c were greater than the values for solutions stored at 25 degrees c. Mark this risk when a client is taking a drug or medication that can interfere with nutrient intake or use. Simply enter a drug andor a nutrient andor an herb into the search field to learn about documented and theoretical interactions. Handbook of drugnutrient interactions nutrition and. Imipenemcilastatin interactions antibiotic medicines can cause diarrhea, which may be a sign of a new infection. Drugnutrient interactions and drugsupplement interactions. Imipenemcilastatin, sold under the brand name primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Imipenem fda orange book approved drug product list. For details, refer to the manufacturers package information as these are not covered in this table. It is known that improper management of some of these interactions may lead to therapeutic failure or cause serious adverse effects to.
Eating grapefruit can inhibit cytochrome p450 34a, slowing metabolism of some drugs eg, amiodarone. If the client is taking a drug or medication that isnt on this list, check the foodmedications interactions book for possible side effects. Food medication interactions 19th edition zaneta m pronsky ms rd ldn fada, dean elbe bsc pharm bcpp pharm d, laura finn bcgp fascp, william roberts md phd, keith ayoob edd rd fada, sol epstein md frcp facp on. This is a useful guide to understanding the science behind nutrient drug interactions. Android phones now shipping for the time being you can only order by. Also, this medicine works best when there is a constant amount in the blood or urine.
Imipenemcilastatin side effects, dosage, interactions. Analysis of possible foodnutrient and drug interactions. Imipenem is a broadspectrum, semisynthetic betalactam carbapenem derived from thienamycin, produced by streptomyces cattleya. If you have diarrhea that is watery or bloody, call your doctor. In the five years since publication of the first edition of the handbook of drugnutrient interactions new perspectives.
Imipenem binds to the bacterial cell wall, resulting in cell death. When a medicine interacts with a nutrient, it can keep the medicine from. Use of prescription or overthecounter drugs or medications shown to interfere with nutrient intake or use, to an extent that nutritional status is compromised. Vitamins and minerals nourish your body and help to keep you healthy and reduce your risk for chronic diseases. Imipenem binds to and inactivates penicillinbinding proteins pbps located on the inner membrane of the bacterial cell wall. Clinical judgment about the disease, alterations in renal or hepatic function, drug interactions, patient response, and laboratory results may dictate modifications. Tables of antibacterial drug dosages red book 2018 red book. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Imipenem is a betalactam antibiotic that is used in combination with cilastatin to treat infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc. This table lists common drugs that can affect nutrition status. Drugs az pill identifier supplements symptom checker diseases dictionary media. Selenium is a trace element that can be found in foods such as seafood, meat, grains, and dairy products. Despite significant interest in such interactions going back to over more than 40 years, the occurrence and clinical significance of many drugnutrient interactions remains unclear. Doctors sometimes prescribe zofran to treat nausea and.
However, interactions involving drugs with a narrow therapeutic margin such as theophylline and digoxin and those that require careful blood monitoring such as. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of. Drugnutrient interactions have been recognized for decades. Cilastatin protects against imipeneminduced nephrotoxicity via. Approved drug products containing imipenem listed in the fda orange book. A drugnutrient interaction is a reaction between a medicine and one or more nutrients. Imipenem c12h17n3o4s cid 104838 structure, chemical names, physical. Furthermore, cilastatin and probenecid ameliorated imipeneminduced rabbit. Drugnutrient interaction checker integrative therapeutics. This medication is known as a carbapenemtype antibiotic. Learn about drug interactions between imipenemcilastatin im and valproic acid oral and use the rxlist drug interaction checker to check drug combinations. The stability of imipenem was dependent on the concentration of that drug in solution. Imipenem and cilastatin is a combination medicine used to treat severe infections of the lower respiratory tract, skin, stomach, or female reproductive organs.
The drugnutrient interactions table may not include every possible interaction. In present study, we hypothesized that drugdrug interactions ddis. Handbook of fooddrug interactions nutrition assessment. View, save, email or print a full interaction report. Developmental toxicity studies with imipenem and cilastatin sodium alone or in combination administered to mice, rats, rabbits, and monkeys at doses 0. Warfarin is commonly used to treat or prevent thromboembolic events. By continuing to browse this site you are agreeing to our use of cookies.
Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intraabdominal infections, and urinary tract infections. Medicine serves to help people when they are sick, allowing them to live longer and healthier lives. Nutrientdrug interactions nutritional disorders merck. Foods can enhance, delay, or decrease drug absorption. Imipenem and cilastatin for injection to reduce the development of drugresistant bacteria and maintain the effectiveness of primaxin i. The effect produced when a drug and a food or beverage are taken at the same time. It offers indepth understanding of the critical role that such interactions may have on the patients outcome. The intramuscular and intravenous formulations of imipenemcilastatin contain 32 mg 1. Nutrient drug interactions effects of nutrition on pharmacokinetics and pharmacodynamics of drugs rebecca white lead pharmacist. Drug interactions may change how your medications work or increase your risk for serious side effects. Important drugnutrient interactions proceedings of the. This document does not contain all possible drug interactions. Drug nutrient interactions table of common drugs and medications.
Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys. The terms nutrientdrug interaction and dietdrug interaction refer to the process whereby the consumption of a food affects the absorption, metabolism, action, retention, andor source for information on nutrientdrug interactions. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. Impact of food on effectiveness of a drug a medication has ingredients, just as food does, that allow it to function correctly when taken in order to help the body in some way. Handbook of drugnutrient interactions boullata, joseph i.
Imipenemcilastatin an overview sciencedirect topics. An example of a side effect are reduced absorption of nutrients, reduced metabolism of the drug, or altered taste of a specific food. Nutrients are the vitamins and minerals that are in the food you eat. Zofran ondansetron side effects, dosage, interactions. Know imipenem uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions.
It has potent activity against grampositive cocci, including some. Combination with cilastatin prevents renal inactivation of imipenem, resulting in high urinary concen. Handbook of drugnutrient interactions nutrition and health. A 65 page ready reckoner with over 400 commonly prescribed drugs, their side effects and interactions good and bad with foods, herbs and nutrients. Dose single dose frequency route instructions adult dosage. Imipenem and cilastatin may also be used for purposes not. Handbook of drugnutrient interactions springerlink. Compiled by accredited practising dietitian, aprof. Imipenem and cilastatin intravenous route, intramuscular.
611 501 1087 1501 331 1606 1301 947 111 884 1077 542 993 129 267 610 873 1097 716 421 1130 1264 183 572 1387 19 634 1238 579 96 77 274 62 40 760 1339 140 565 638 778 56 1288 778 72